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New drug turns off 'go' switch in prostate cancer cells and halts disease

April 4, 2012 - Washington

A new drug prevents human prostate cancer cells from spreading to other tissues without any toxic effects to normal cells or tissues by turning off the "go" switch in the cancer cells and immobilizing them.

Northwestern Medicine scientists who developed the drug, called KBU2046, believe that prostate cancer patients treated with it may not need more aggressive procedures.

prostate cancer is the second-leading cause of cancer death in North American males. Death is mainly caused by metastasis, prostate cancer cells moving out of prostate tissue and spreading to other organs.

"This is an extremely promising new therapeutic that locks down aggressive prostate cancer cells so they don't move," said Raymond Bergan, M.D., director of experimental therapeutics for the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

"The spread of prostate cancer is what kills men. Cancer cells have a switch that tells them to keep moving all the time. This drug turns it off," Bergan explained.

The drug works by binding to and disabling proteins in the cancer cell that instruct it to move, said Bergan, a professor of medicine at Northwestern's Feinberg School of Medicine and a physician at Northwestern Memorial Hospital.

Li Xu, a research assistant professor of medicine at the Feinberg School, helped develop the drug, along with Karl Scheidt, an associate professor of chemistry at the Weinberg College of Arts and Sciences.

In the study, Northwestern researchers transplanted aggressive human prostate cancer cells into mice prostate tissue and fed the mice with the new drug for five weeks. The drug inhibited movement of the cells and prevented them from metastasizing to the lung, one of the tissues to which prostate cancer spreads in men.

Xu said she conducted extensive toxicity studies, including on normal human cells, and found that the drug is nontoxic and does not cause any harmful effects.

"We envision that this drug, if shown to be effective in clinical trials, could be used to treat men diagnosed with prostate cancer, so they wouldn't need more aggressive procedures. Or, the drug could augment the effectiveness of surgery and radiation," Bergan said.

Bergan hopes to test the drug in a clinical trial.

Xu presented the finding at the American Association for Cancer Research Annual Meeting 2012 in Chicago, April 3.


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