tool make fight
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Twitter ~ Facebook
Home / Technology News / 2010 / October 2010 / October 9, 2010
New tool to make fight against tuberculosis easier
RSS / Print / Comments

Tuberculosis

New tool to make fight against tuberculosis easier

Seven Secure Oslo Business for Peace Awards for 2010

New TB pathogen discovered

More on Tuberculosis

University of Illinois

New tool to make fight against tuberculosis easier

Evidence of unusual drug-resistant breast tumours found

Corporate Social Responsibility Weekly Recap (September 29 – October 6, 2010)

More on University of Illinois

Technology News

Study to find whether leptin helps type 1 diabetic patients
To determine whether adding the hormone leptin to standard insulin therapy might help rein in the tumultuous blood-sugar levels of people with type 1 (insulin-dependent) diabetes, a clinical trial at UT Southwestern Medical Center is being carried out. ANI

Why deaf have 'super vision'
Researchers have found reasons for the enhanced abilities in the remaining senses of deaf people. ANI

Tsunami risk higher than expected in LA, other major cities
A new study has revealed that the risk of destructive tsunamis is in places such as Kingston, Istanbul, and Los Angeles. ANI

New tool to make fight against tuberculosis easier

Researchers have developed an algorithm that integrates genomic and metabolic data and enables cell-scale simulations.


Washington, Oct 9 : Researchers have developed an algorithm that integrates genomic and metabolic data and enables cell-scale simulations.

Researchers at the Institute for Genomic Biology at the University of Illinois have developed a way to harness the prodigious quantities of both genomic and metabolic data being generated with high-throughput genomics and other techniques.

The model, called probabilistic regulation of metabolism (PROM), enables researchers to perturb a given regulatory gene or metabolic process and see how that affects the entire network.

"PROM provides a platform for studying the behaviours of networks in a wide range of different conditions," said principal investigator Nathan Price.

Using this model the researchers have created the first genome-scale, regulatory-metabolic network of Mycobacterium tuberculosis.

Using E. Coli as a benchmark, Price and Sriram Chandrasekaran showed that PROM was more accurate and comprehensive than the previous model for E. Coli, which had been done by hand and published in 2004.

Price and Chandrasekaran built the algorithm using microarray data, transcription-factor interactions that regulate metabolic reactions, and knockout phenotypes.

The method is both accurate and fast. PROM may prove particularly helpful to tuberculosis researchers because, although when tuberculosis is growing it can be killed, the real challenge is to target the bacterium during its dormant or quiescent stage.

PROM may enable researchers to identify and target the pathways keeping the cells alive during dormancy.

PROM also represents a major advance because it successfully integrates the statistically derived transcriptional regulatory network with a biochemically derived metabolic network.

The results were published online in the journal PNAS.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2017 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us