Functional artificial pancreatic tissue offers
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Twitter ~ Facebook
Home / Technology News / 2010 / October 2010 / October 8, 2010
Functional artificial pancreatic tissue offers new hope to diabetics
RSS / Print / Comments


Reportlinker Adds Global Milk Industry

Cellular defect that leads to cancer discovered

Why family history ups Alzheimers risk - especially from the maternal side

More on Protein


Paralysed patient becomes world's first to get stem cell therapy

Study to find whether leptin helps type 1 diabetic patients

Blame your mom for your muffin top or thunder thighs

More on Diabetes

Technology News

Squeezable cell phone to give you status info without having to look at it
Scientists have developed a squeezable cellphone - SqueezeBlock - using tiny motors built into the casing to mimic the behaviour of a spring. ANI

Airplanes that also travel in space to be 'the holy grail' of aeronautics
A British firm is working on an airplane that would also travel in space. ANI

Was Oz-Indian scientist first to discover recently found Earth-like planet?
The recent discovery of Earth-like planet caused a tizzy in the science world, but many are still sceptical of the claim. ANI

Functional artificial pancreatic tissue offers new hope to diabetics

Researchers have found a completely new way of controlling insulin dependent diabetes without daily injections of insulin.

Washington, Oct 8 : Researchers have found a completely new way of controlling insulin dependent diabetes without daily injections of insulin.

Surgeons from Ma*sachusetts General Hospital, Boston have bio engineered a novel matrix that serves as a scaffold for seeding supportive stem cells as well as pancreatic islets (the cells that produce insulin in the pancreas).

The researchers note that the matrix not only helps to understand the micro-architecture of the pancreas, but also prolongs the survival and preserves the function of the islets.

Islets survived longer in the bio-artificial matrix than in conventional transplantation sites, and they produced significantly more insulin when challenged with glucose.

"Islet cell transplantation is the only treatment of insulin dependent diabetes that can consistently establish insulin independence," said Claudius Conrad of the Ma*sachusetts General Hospital.

However, islets only feel at home in the pancreatic niche, and therefore their survival and ability to produce insulin declines rapidly if transplanted, for example, in the liver.

"The pancreas provides a very special environment for islets. By default, the survival and function of the islet cells will always be worse in any organ other than the pancreas.

To engineer an endocrine pancreas, islet- and stem cells require an extracellular matrix (ECM) that provides specific archi- tecture, microstructure, and most importantly microvasculature to form the islet cell specific niche," he said.

Conrad and his colleagues are attempting to form a cellular structure that mimics the natural resting place on which the islets thrive.

"We are trying to improve the survival and the functionality of the islets by creating their pancreas specific niche," he explained.

The matrix was formed by removing cells from pancreatic tissue with biological deter-gents so only the proteins that hold the cells together were left.

The resulting matrix was seeded with donor islet cells and supportive stem cells, and the entire construct was successfully trans-planted and maintained in a recipient animal model using microsurgical techniques.

The findings were presented at the Annual Clinical Congress of the American College of Surgeons.


Link to this page

Suggested pages for your additional reading on Facebook

© 2000-2017 All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us