Immune response pregnancy
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Twitter ~ Facebook
Home / Technology News / 2010 / October 2010 / October 13, 2010
Immune response in pregnancy 'can lead to brain dysfunction in child'
RSS / Print / Comments

Columbia University

Immune response in pregnancy 'can lead to brain dysfunction in child'

Immune response in pregnancy 'can lead to brain dysfunction in child'

How stem cells shape up to their surroundings

More on Columbia University

pregnancy

Metabolic status prior to pregnancy predicts subsequent gestational diabetes

Immune response in pregnancy 'can lead to brain dysfunction in child'

Mums win hands-down when it comes to naming babies

More on pregnancy

Protein

Reportlinker Adds Global Milk Industry

Cellular defect that leads to cancer discovered

Why family history ups Alzheimers risk - especially from the maternal side

More on Protein

Technology News

Now, laser technology that destroys tumours using heat
Scientists have developed a technique that heats up and destroys kidney and liver tumours. ANI

Cheap, solar-powered lamp 'most important object of the 21st century'
A cheap solar-powered lamp has joined the list of the most priceless treasures in the British Museum. ANI

Worms provide clues to declining fertility with age in women
A new study from Princeton University has revealed why fertility declines at a rate that far exceeds the onset of other aging signs in women. ANI

Immune response in pregnancy 'can lead to brain dysfunction in child'

A pregnant womans immune response to viral infections may induce subtle neurological changes in the unborn child that can lead to an increased risk for neurodevelopmental disorders including schizophrenia and autism.


Washington, Oct 13 : A pregnant woman's immune response to viral infections may induce subtle neurological changes in the unborn child that can lead to an increased risk for neurodevelopmental disorders including schizophrenia and autism.

Research provides new insights into how this may happen and suggests potential strategies for reducing this risk.

"Infection during pregnancy is associated with increased risk of damage to the developing nervous system. Given that many agents have been implicated, we decided to focus on mechanisms by which the maternal immune response, rather than direct infection of the fetus, might contribute to behavioral disturbances in the offspring of mothers who suffer infection during pregnancy," says W. Ian Lipkin of Columbia University, senior author on the study.

To better understand how the immune response causes these neurological changes, the researchers exposed pregnant mice to a synthetic molecular mimic of a replicating virus. Offspring of the exposed mice had impaired locomotor activity compared to controls. Further testing determined that the exposure inhibited embryonic neuronal stem cell replication, affecting brain development.

They also looked at the potential role of an immune protein known as Toll-like receptor 3 (TLR3) which is commonly activated in viral infections. Using TLR3-deficient mice they determined that the effects of exposure were dependent on TLR3. They also investigated whether the drug carprofen, a non-steroidal anti-inflammatory drug, would have any effect. Pretreatment with the drug abrogated the effects of exposure.

"Our findings provide insights into mechanisms by which maternal infection may induce subtle changes in brain and behavior and suggest strategies for reducing the risk of neuropsychiatric diseases following exposures to infectious agents and other triggers of innate immunity during gestation," says Lipkin.

The study has been published in the online journal mBio.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2017 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us