Cellular defect that leads
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Twitter ~ Facebook
Home / Technology News / 2010 / March 2010 / March 17, 2010
Cellular defect that leads to cancer discovered
RSS / Print / Comments

Brain cancer

TTF therapy, chemo combo 'increase survival for lung cancer patients'

How genetic changes make some brain cancers more aggressive

Pavin brings in F-16 fighter pilot to motivate US golf team ahead of Ryder Cup

More on Brain cancer

Protein

Reportlinker Adds Global Milk Industry

Cellular defect that leads to cancer discovered

Why family history ups Alzheimers risk - especially from the maternal side

More on Protein

Prostate cancer

Gender-bending chemical in plastics 'ups prostate cancer risk'

New Data for Erbitux in Prevalent Cancers to Be Revealed at ESMO

People with cancer history prone to memory impairment

More on Prostate cancer

Colorectal cancer

Low socioeconomic status linked to severe colorectal cancer

GlobeImmune Announces Late-Breaker Oral Presentation of GI-5005 Prior Non-Responder Data at AASLD 2010 Meeting

Signature Diagnostics Appoints Rainer Kramer to Chief Business Officer and Member of the Management Board

More on Colorectal cancer

Breast cancer

Sysmex Announces Establishment of Overseas Subsidiary in Spain to Expand Life Science Business

Breast cancer multigene test may help patients avoid chemo

Mangoes may protect against breast, colon cancer

More on Breast cancer

Technology News

Study to find whether leptin helps type 1 diabetic patients
To determine whether adding the hormone leptin to standard insulin therapy might help rein in the tumultuous blood-sugar levels of people with type 1 (insulin-dependent) diabetes, a clinical trial at UT Southwestern Medical Center is being carried out. ANI

Why deaf have 'super vision'
Researchers have found reasons for the enhanced abilities in the remaining senses of deaf people. ANI

Tsunami risk higher than expected in LA, other major cities
A new study has revealed that the risk of destructive tsunamis is in places such as Kingston, Istanbul, and Los Angeles. ANI

Cellular defect that leads to cancer discovered

Scientists at the University of California, San Francisco researchers have found that a key cellular defect that disturbs the production of proteins in human cells can lead to cancer susceptibility.


Washington, March 17 : Scientists at the University of California, San Francisco researchers have found that a key cellular defect that disturbs the production of proteins in human cells can lead to cancer susceptibility.

They also discovered that a new generation of inhibitory drugs offers promise in correcting this defect.

According to researchers, their finding has broad clinical implications in the fight against cancer and could affect treatment of lymphoma and many other forms of the disease, including prostate cancer, breast cancer, colorectal cancer, brain cancer and multiple myeloma.

The discovery was made in the laboratory of UCSF faculty scientist Davide Ruggero, whose lab team is doing research in the burgeoning field of study on how defects in protein synthesis can lead to cancer susceptibility.

"Our work has the potential to create real, tangible benefits for the medical community," said Ruggero.

The researchers focused on a multi-protein unit known as mTOR, which stands for the "mammalian target of rapamycin." mTOR controls several important processes in mammalian cells, including cell survival and proliferation.

One of the most significant of these processes is the production of proteins within a cell, the control of which is known as translational control. mTOR integrates information about the cell's nutritional and energy needs, and prompts the cell to manufacture key proteins for cell growth. Cancer cells exploit this signal for their own growth.

According to the researchers, when the cells in the body lose the ability to control mTOR activity, mTOR is considered "hyperactivated."

This hyperactivation causes protein synthesis rates to climb. Cells begin to proliferate without limits and simultaneously become immortal, all of which leads to tumour formation.

The findings are featured as the cover story in the March 16, 2010 issue of the scientific journal Cancer Cell.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2017 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us