Nausea drug help
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Twitter ~ Facebook
Home / Technology News / 2010 / February 2010 / February 15, 2010
Nausea drug may help treat heart disease and stroke
RSS / Print / Comments


Reportlinker Adds Global Milk Industry

Cellular defect that leads to cancer discovered

Why family history ups Alzheimers risk - especially from the maternal side

More on Protein

Massachusetts General Hospital

Functional artificial pancreatic tissue offers new hope to diabetics

How iron overload 'speeds up' Alzheimer's

Saturated fat not as bad as previously thought

More on Massachusetts General Hospital

Heart attack

More strokes, fewer heart attacks with carotid stents: Study

Insulin resistance may be linked to stroke risk

European Medicines Agency approves TWYNSTA® (telmisartan plus amlodipine) a new single pill combination that delivers powerful and consistent blood pressure reductions throughout 24 hours

More on Heart attack

University of Rochester

Adhering to healthy lifestyle lowers breast cancer risk

Adhering to healthy lifestyle lowers breast cancer risk

Molecular 'playbook' to stop heart failure risk factor found

More on University of Rochester

Technology News

Changes in population growth and composition influence climate change
A new study has suggested that changes in population growth and composition, including aging and urbanization, could affect global emissions of carbon dioxide over the next 40 years. ANI

Chinese scientists, explorers seek help in search for elusive ape-man
Chinese scientists and explorers are looking for international help as they begin a new search for the elusive ape-man known as Bigfoot or Yeren. ANI

Magnets may help treat major depression
Psychiatric researchers at Rush University Medical Center have found a non-invasive, non-drug therapy to be an effective, long-term treatment for major depression. ANI

Nausea drug may help treat heart disease and stroke

American scientists have identified new effects of drugs approved by Food and Drug Administration (FDA) drugs, which can help shift cellular energy metabolism and may even come useful in the treatment of cardiovascular disease.

London, Feb 15 : American scientists have identified new effects of drugs approved by Food and Drug Administration (FDA) drugs, which can help shift cellular energy metabolism and may even come useful in the treatment of cardiovascular disease.

The findings of the study team, led by Massachusetts General Hospital (MGH) researchers, have appeared in Nature Biotechnology.

One of the key findings of the study was meclizine, a well-known nausea drug, may help treat heart disease and stroke.

Initial studies in animals using meclizine, a drug commonly used to treat nausea and vertigo, have given favourable results in treating cardiovascular diseases and stroke.

Vamsi Mootha of the MGH Center for Human Genetic Research, who led the study, said: "Shifts in cells' energy production pathways take place naturally during development and in response to demanding activities - like sprinting versus long-distance running. They are also known to be involved in several disease states.

"We wanted to identify compounds that can safely induce this shift - those that have previously been discovered are too toxic - and investigate their therapeutic potential in animal models."

Usually cells convert nutrients into energy by relying on two cellular processes. One involves the uptake of sugars that are broken down in the cytoplasm into a molecule called lactate by a process called glycolysis, which quickly yields a small amount of ATP, the enzyme that provides cellular energy. Alternatively, sugars and proteins can be processed in cellular structures called mitochondria to release greater amounts of ATP through a more efficient process called cellular respiration.

In cancer cells and other rapidly proliferating cells, energy is produced predominantly by glycolysis, suggesting that a shift away from that mechanism might suppress tumour growth. Previous animal studies suggested that a reduction in mitochondrial respiration could mimic a process called ischemic preconditioning, in which brief episodes of ischemia - a reduction in blood flow - actually protect tissue against being damaged if its blood supply is later cut off completely.

To look for compounds that shift cells from respiration to glycolysis, Mootha's team devised a unique screening strategy. The scientists cultured skin cells in two different nutrient environments - glucose, which provides energy through both glycolysis and respiration, or galactose, which forces cells to rely on mitochondrial respiration alone. A drug that redirects energy metabolism from respiration to glycolysis would stop growth in the galactose-cultured cells while having little effect on cells grown in glucose.

Their initial screen of almost 3,700 compounds, including nearly half of all FDA-approved drugs, found several drugs known to inhibit cellular respiration on one end of the scale and several anti-cancer drugs that halt the growth of rapidly proliferating cells at the other, which verified the approach.

Because most agents known to mimic ischemic preconditioning in animal models are too toxic to use in human patients, the researchers were quite eager to find drugs that cause subtle metabolic shifts. The screen identified eight approved drugs that produced a less pronounced but still significant shift away from cellular respiration. One of those agents was meclizine.

To study meclizine's potential to prevent tissue damage in heart attack or stroke, Mootha's team joined hands with University of Rochester researchers who had developed rat models of heart attack damage and an MGH Pathology group with a mouse model of stroke damage.

Blinded experiments using both animal models showed that pretreatment with meclizine dramatically reduced ischemic damage to cardiac cells in the heart attack model and to brain cells in the stroke model. They also discovered that meclizine's ischemia protective effects do not appear to involve its known mechanisms.

While the study results suggest that treatment with drugs like meclizine may someday be useful for reducing the damage associated with heart attack or stroke, Mootha believes much additional study is needed.

He said: "Before we can think about human studies, we need to do rigorous animal testing to determine optimal, safe dosing regimens and learn more about how this drug works."


Link to this page

Suggested pages for your additional reading on Facebook

© 2000-2018 All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us