Evolution made human race more
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Twitter ~ Facebook
Home / Technology News / 2010 / August 2010 / August 18, 2010
Evolution made human race more susceptible to diabetes: Study
RSS / Print / Comments

Diabetes

Study to find whether leptin helps type 1 diabetic patients

Blame your mom for your muffin top or thunder thighs

Clinical trials show effective weight loss strategies for obese

More on Diabetes

Stanford University School of Medicine

How body clock and sleep affect brain connections between night and day

Now, a blood test to detect organ transplant rejection

Repeated antibiotic use alters beneficial gut microbes

More on Stanford University School of Medicine

Malaria

New gene study paves way for more anti-malaria treatments

Seven Secure Oslo Business for Peace Awards for 2010

Fans accuse Cheryl Cole of choosing two worst singers for 'X Factor' finals

More on Malaria

Technology News

Study to find whether leptin helps type 1 diabetic patients
To determine whether adding the hormone leptin to standard insulin therapy might help rein in the tumultuous blood-sugar levels of people with type 1 (insulin-dependent) diabetes, a clinical trial at UT Southwestern Medical Center is being carried out. ANI

Why deaf have 'super vision'
Researchers have found reasons for the enhanced abilities in the remaining senses of deaf people. ANI

Tsunami risk higher than expected in LA, other major cities
A new study has revealed that the risk of destructive tsunamis is in places such as Kingston, Istanbul, and Los Angeles. ANI

Evolution made human race more susceptible to diabetes: Study

Earlier humans with genes that were prone to type-1 diabetes and rheumatoid arthritis may have provided them with previously unknown benefits, as a result of which, over the years, the modern man has become more prone to some complex diseases, says a new study.


Washington, Aug 18 : Earlier humans with genes that were prone to type-1 diabetes and rheumatoid arthritis may have provided them with previously unknown benefits, as a result of which, over the years, the modern man has become more prone to some complex diseases, says a new study.

Researchers at the Stanford University School of Medicine speculate that at least some of the risky changes may protect carriers against certain viruses and bacteria.

However, whether the beneficial effects arise from the disease-associated mutations themselves, or from neighbouring genes that tag along when DNA is divvied up into sperm and eggs, is not clear.

The idea that disease-causing genes can be beneficial is not new. For instance, a gene variant that, when present in two copies, causes sickle cell anaemia is beneficial because a single copy of it makes the person less susceptible to malaria.

Many complex diseases are associated with several variants - specific locations in the DNA where the nucleotide "letters" vary between individuals. These locations are known as SNPs, for single nucleotide polymorphisms.

Graduate student Erik Corona found that of the top SNPs associated with type-1 diabetes, 80 have been recently increasing in prevalence.

Similarly, SNPs associated with an increased risk for rheumatoid arthritis were found to be positively selected.

"It's possible that, in areas of the world where associated triggers for some of these complex conditions are lacking, carriers would experience only the protective effect against some types of infectious disease," said Atul Butte.

Regardless of the reason, some evolutionary tenets still apply. Healthier people are, presumably, more likely to reproduce and pass those same genes - be they protective or risky - to their offspring.

With differences in diet, exposures or location as populations move around the globe, carriers of the risky SNPs began to develop the conditions we struggle with today.

Corona and Butte are now expanding their investigation to include even more SNPs and diseases. They are also looking at the genetic profile of various types of tumours to see if there's evidence for positive evolutionary pressure there as well.

The research will be published Aug. 17 in Public Library of Science ONE.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2017 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us