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/ Technology News / 2009 / December 2009 / December 25, 2009 |
Reportlinker Adds Global Milk Industry
Cellular defect that leads to cancer discovered
Why family history ups Alzheimers risk - especially from the maternal side
Algorithm to separate blood sample into different cell types and detect changes
Reduction of salt in processed foods could save lives, money
Scientists to map Chile earthquake site to capture fresh data
A team of scientists are all set to undertake an expedition to explore the rupture site of the 8.8-magnitude Chilean earthquake, which is one of largest quakes in recorded history. ANI
Signature of renaissance artist Raphael found hidden in painting
Reports indicate that art experts have found what they believe is the earliest signature of the master renaissance artist Raphael, hidden within a paintings arabesque decorations. ANI
How global warming can lead to increased violence in human beings
A new research has shown that as the earths average temperature rises, so does human heat in the form of violent tendencies, which links global warming with increased violence in human beings. ANI
Scientists from Stanford University School of Medicine have identified a protein that appears to play a critical role in keeping stem cells poised to quickly become more specialized cell types.
Washington, Dec 25 : Scientists from Stanford University School of Medicine have identified a Protein that appears to play a critical role in keeping stem cells poised to quickly become more specialized cell types.
The protein called Jarid2 maintains a delicate balancing act - one that both recruits other regulatory Proteins to genes important in differentiation and also modulates their activity to keep them in a state of ongoing readiness.
"Understanding how only the relevant genes are targeted and remain poised for action is a hot topic in embryonic stem cell research," said Dr Joanna Wysocka, assistant professor of developmental biology and of chemical and systems biology.
"Our results shed light on both these questions," Wysocka added.
Jarid2 works through a protein complex called PRC2, for Polycomb Repressive Complex 2, which is necessary to regulate the expression of developmentally important genes in many types of cells.
According to the researchers, PRC2 activity allows the cell to carefully manage its degree of readiness for the subsequent unwrapping and expression of genes involved in differentiation of the embryonic stem cells into more specialized cells.
"It was just as we would have predicted," said Wysocka. "Without Jarid2, which keeps the genes silent yet poised for activation, the embryos stop developing."
The researchers now plan to further investigate the mechanism by which Jarid2 summons PRC2 to differentiation-specific genes in the stem cells, and how it affects gene expression.
The interaction may be important in human cancers as well.
The study appears in journal Cell.
ANI
