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/ Technology News / 2008 / November 2008 / November 4, 2008 Half-broken gene is more than enough to cause cancer |
Planck satellite sees giant filaments of cold dust stretching through our galaxy
A new image from ESAs (European Space Agencys) Planck satellite has revealed giant filaments of cold dust stretching through our Galaxy. ANI
Urgent law enforcement action needed to deal with illegal ivory trade in Africa and Asia
A new analysis of elephant trade data has indicated that urgent law enforcement action by governments in Central and West Africa and South-east Asia is crucial to addressing the illicit ivory trade. ANI
New method uses super-sexed but sterile male insects for sustainable pest control
Agricultural researchers at the Hebrew University of Jerusalem are developing an improved method for sustainable pest control using super-sexed but sterile male insects to copulate with female ones. ANI
A single allele of tumour suppressor genes is enough to put a person at risk of cancer, according to a new study.
Washington, Nov 4 : A single allele of tumour suppressor genes is enough to put a person at risk of cancer, according to a new study.
In the study focussing on SMAD4, a tumour suppressor gene implicated in pancreatic and colorectal cancer, the researchers found that such genes don't really need both alleles to be knocked out before disease phenotypes are expressed.
Led by Riccardo Fodde from Erasmus MC, Rotterdam, the researchers found that only one allele of SMAD4 has to be damaged to put a person at risk of pancreatic and colorectal cancer.
They found that having one mutated SMAD4 allele was associated with the development of gastrointestinal polyps.
This is the first study to deal with the molecular and cellular consequences of SMAD4 damage on a genome-wide scale.
The study was published in BioMed Central's new open access journal PathoGenetics.
ANI
