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MRI's 'may become powerful new tools to monitor cholesterol drugs'

October 15, 2011 - Washington

MRI scanning could serve as a powerful new tool to assess how well cholesterol drugs are working, a US scientist says.

Loyola University Health System cardiologist Binh An P. Phan, MD conducted an MRI study of 120 patients who had recently begun taking cholesterol medications.

The study found that intensive treatment with cholesterol drugs significantly reduced the amount of cholesterol in artery-clogging plaque.

cholesterol is the raw material in the buildup of plaque, which leads to atherosclerosis (hardening of the arteries). The process can cause blocked arteries that can trigger heart attacks, strokes and other cardiovascular problems.

Imaging technologies traditionally used to monitor cardiovascular disease, such as angiograms and ultrasounds, show the overall size of the plaque buildup. In the new study, MRI scans were more precise, showing the amount of cholesterol within the plaque.

After three years, the 33 patients with identified carotid plaques had a significant reduction in the cholesterol within the plaque. The volume of cholesterol dropped from 60.4 cubic millimeters to 37.4 cubic millimeters, and the percentage of plaque volume consisting of cholesterol dropped from 14.2 percent to 7.4 percent.

The findings confirmed the researchers' hypothesis that the reason why cholesterol medications shrink the overall size of the plaque is because cholesterol is being removed from within the plaque.

Thus, using MRI scans to monitor the amount of cholesterol in plaque may help doctors to better determine how well cholesterol medications are working. If an MRI showed cholesterol was not being reduced, more aggressive therapy might be needed, Phan said.

"In the future, MRI scans may become important and powerful tools to see how medication therapy is working inside arteries," he added.

The study has been published in the Journal of the American College of Cardiology: Cardiovascular Imaging.


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