Exercise caloric restriction delay
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Breast Cancer ~ Swine Flu ~ Lung Cancer ~ Heart attack ~ Pregnancy ~ All Health Topics
Home / Health News / 2010 / August 2010 / August 3, 2010
Exercise, caloric restriction may delay debilitating effects of aging
RSS / Print / Comments

Harvard University

Whale poop ups productivity of ocean fisheries

Our brains more responsive to friends than to strangers: Study

Americans have more 'negative view' of govt than a decade ago:Poll

More on Harvard University

Health News

Blame your mom for your muffin top or thunder thighs
A new study by an international team of researchers, including Cambridge and Oxford experts, has revealed that our propensity to be apple or pear-shaped is at least partly in our genes. ANI

Blame your mom for your muffin top or thunder thighs
A new study by an international team of researchers, including Cambridge and Oxford experts, has revealed that our propensity to be apple or pear-shaped is at least partly in our genes. ANI

Meta-analysis shows folic acid supplements not beneficial for heart
A new meta-analysis has shown that the use of folic acid supplements does not appear to be associated with reduced rates of cardiovascular events, cancer or death over a five-year period. ANI

Exercise, caloric restriction may delay debilitating effects of aging

A new research at the Harvard University has found out a mechanism through which caloric restriction and exercise may delay some of the debilitating effects of aging by rejuvenating connections between nerves and the muscles that they control.


Washington, Aug 03 : A new research at the Harvard University has found out a mechanism through which caloric restriction and exercise may delay some of the debilitating effects of aging by rejuvenating connections between nerves and the muscles that they control.

The research further explains earlier findings that exercise and restricted-calorie diets help to stave off the mental and physical degeneration of aging.

"Caloric restriction and exercise have numerous, dramatic effects on our mental acuity and motor ability," said Joshua Sanes, a professor of molecular and cellular biology and director of the Center for Brain Science at Harvard University.

"This research gives us a hint that the way these extremely powerful lifestyle factors act is by attenuating or reversing the decline in our synapses," he added.

Sanes said that the study was conducted on genetically engineered so that their nerve cells glow in fluorescent colors.

It shows that some of the debilitation of aging is caused by deterioration of connections that nerves make with the muscles they control, structures called neuromuscular junctions.

These microscopic links are remarkably similar to the synapses that connect neurons to form information-processing circuits in the brain.

In a healthy neuromuscular synapse, nerve endings and their receptors on muscle fibers are almost a perfect match, like two hands placed together, finger to finger, palm to palm.

This lineup ensures maximum efficiency in transmitting the nerve's signal from the brain to the muscle, which is what makes it contract during movement.

As people age, however, the neuromuscular synapses can deteriorate in several ways. Nerves can shrink, failing to cover the muscle's receptors completely.

The resulting interference with transmission of nerve impulses to the muscles can result in wasting and eventually even death of muscle fibers.

This muscle wasting, called sarcopenia, is a common and significant clinical problem in the elderly.

The new work showed that mice on a restricted-calorie diet largely avoid that age-related deterioration of their neuromuscular junctions, while those on a one-month exercise regimen when already elderly partially reverse the damage.

"With calorie restriction, we saw reversal of all aspects of the synapse disassembly. With exercise, we saw a reversal of most, but not all," Sanes said.

The study was published in the journal Proceedings of the National Academy of Sciences.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2018 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us