Vitamin halt weakening
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Breast Cancer ~ Swine Flu ~ Lung Cancer ~ Heart attack ~ Pregnancy ~ All Health Topics
Home / Health News / 2009 / May 2009 / May 21, 2009
Vitamin D may halt weakening of asthmatics lung function
RSS / Print / Comments

University of Pennsylvania

Thinking about time will inspire you to be with loved ones

Our eyes evolved to see dark world

1 in 3 Brits don't indulge in weekend lie-ins anymore

More on University of Pennsylvania

Asthma

Bacteria linked to asthma attacks in children

US study finds smoking, ADHD link

More on Asthma

Health News

New study confirms smoking, cancer link (reissue)
Taking up smoking results in epigenetic changes associated with the development of cancer, UK scientists have reported. ANI

Blame your mom for your muffin top or thunder thighs
A new study by an international team of researchers, including Cambridge and Oxford experts, has revealed that our propensity to be apple or pear-shaped is at least partly in our genes. ANI

Chemicals in mother's blood linked to child's obesity
A team of scientists has revealed that babies whose mothers had relatively high levels of the chemical DDE in their blood were more likely to both grow rapidly during their first 6 months and to have a high body ma*s index (BMI) by 14 months. ANI

Vitamin D may halt weakening of asthmatics lung function

Researchers at the University of Pennsylvania have found that vitamin D may slow the progressive decline in asthmatics ability to breathe as a result of human airway smooth muscle (HASM) proliferation.


Washington, May 21 : Researchers at the University of Pennsylvania have found that vitamin D may slow the progressive decline in asthmatics' ability to breathe as a result of human airway smooth muscle (HASM) proliferation.

In their study, the researchers found that calcitriol, a form of vitamin D synthesized within the body, reduced growth-factor-induced HASM proliferation in cells isolated from both persons with asthma and from persons without the disease.

The proliferation is a part of process called airway remodeling, which occurs in many people with asthma, and leads to reduced lung function over time.

According to researchers, by slowing airway remodeling, the decline in breathing that leaves many asthmatics even more vulnerable when they suffer an asthma attack can be prevented.

"Calcitriol has recently earned prominence for its anti-inflammatory effects. But our study is the first to reveal the potent role of calcitriol in inhibiting ASM proliferation," said Gautam Damera, Ph.D

The studies were carried out with cells from 12 subjects, and the researchers compared calcitriol with dexmethasone, a corticosteroid prescribed widely for the treatment of asthma.

Although, dexmethasone is also a powerful anti-inflammatory agent, the researchers found that it had little effect on HASM growth.

Damera and his colleagues found calcitriol inhibits HASM in a dose-dependent manner.

They also conducted experiments to determine the mechanism by which calcitriol retards HASM proliferation.

They believe the vitamin works by inhibiting activation of distinct set of proteins responsible for cell-cycle progression.

The study has been presented at the American Thoracic Society's 105th International Conference in San Diego on Wednesday, May 20.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2017 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us