Microscopic beads
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Breast Cancer ~ Swine Flu ~ Lung Cancer ~ Heart attack ~ Pregnancy ~ All Health Topics
Home / Health News / 2009 / July 2009 / July 7, 2009
Microscopic beads may revolutionise organ transplantation
RSS / Print / Comments

Health News

Waist size, not BMI can foretell cardiovascular risk in children
A new study by researchers at the University of Georgia, the Menzies Research Institute in Hobart, Australia and the Murdoch Childrens Research Institute in Melbourne, Australia has found that waist circumference is a better indicator of a childs risk for cardiovascular disease and diabetes later in life, as compared to BMI. ANI

Internal body temperature regulates body clock
Fluctuations in internal body temperature regulate the bodys circadian rhythm, the 24-hour cycle that controls metabolism, sleep and other bodily functions, revealed UT Southwestern Medical Center researchers. ANI

Egyptian mummies discovery indicates 'cancer is man-made'
A study of ancient remains has found that cancer is a man-made disease fuelled by pollution and changes to diet and lifestyle. ANI

Microscopic beads may revolutionise organ transplantation

If Medical College of Georgia researchers are to be believed, organ transplantation in future may include microscopic beads that create designer immune cells so that patients may tolerate their new organ.


Washington, July 7 : If Medical College of Georgia researchers are to be believed, organ transplantation in future may include microscopic beads that create "designer" immune cells so that patients may tolerate their new organ.

Dr. Anatolij Horuzsko, reproductive immunologist at the MCG Center for Molecular Chaperone/Radiobiology and Cancer Virology, has already used this approach successfully in mice with skin grafts.

"It's absolutely natural," says the researcher.

The degradable microparticles deliver the most powerful known form of HLA-G, a natural suppressor of the immune response, straight to dendritic cells, which typically show the immune system what to attack.

The microparticles are given right after a transplant, just as dendritic cells are giving the immune system a heads up to get busy attacking the new organ.

Dr. Horuzsko says that microparticle therapy likely would be needed for just a few weeks, until the dendritic cells have learned instead to ignore it.

"It's like a calming effect and once tolerance is established, we don't need it any more," he says.

His team compared the success of HLA-G microparticles with the dendritic cell marker to those without a marker, those with were much more efficient at getting where needed and acting.

He says that those without direction likely were consumed by garbage eaters called macrophages.

"We want to create in kidney transplant patients, the same tolerance to the new kidney," says Dr. Horuzsko, who reckons that HLA-G microparticles could be doing just that within five years.

He presented the patented process along with his other latest HLA-G findings during an opening lecture of the 5th International Conference on HLA-G in Paris, July 6-8.

Dr. Horuzsko believes that marked microparticles also have treatment potential in diseases where the immune system attacks normal tissue, such as arthritis, multiple sclerosis and inflammatory bowel disease.

He is currently working in collaboration with Dr. Laura Mulloy, chief of the Section of Nephrology, Hypertension and Transplantation Medicine in the MCG School of Medicine, to find out whether higher natural levels of HLA-G already are giving some transplant patients an edge, by comparing HLA-G expression in those who keep and reject their transplanted kidneys.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2017 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us