Urine ELISA
Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Sports ~ Technology ~ Health ~ Features
Breast Cancer ~ Swine Flu ~ Lung Cancer ~ Heart attack ~ Pregnancy ~ All Health Topics
Home / Health News / 2009 / August 2009 / August 28, 2009
Urine LAM-ELISA not effective as independent diagnostic test for pulmonary TB
RSS / Print / Comments

Tuberculosis

New tool to make fight against tuberculosis easier

Seven Secure Oslo Business for Peace Awards for 2010

New TB pathogen discovered

More on Tuberculosis

University College London

Paralysed patient becomes world's first to get stem cell therapy

Foetus captured on film smiling at just 17 weeks

UK varsity report suggests measures to prevent Islamic radicalisation of students

More on University College London

Health News

Blame your mom for your muffin top or thunder thighs
A new study by an international team of researchers, including Cambridge and Oxford experts, has revealed that our propensity to be apple or pear-shaped is at least partly in our genes. ANI

Blame your mom for your muffin top or thunder thighs
A new study by an international team of researchers, including Cambridge and Oxford experts, has revealed that our propensity to be apple or pear-shaped is at least partly in our genes. ANI

Meta-analysis shows folic acid supplements not beneficial for heart
A new meta-analysis has shown that the use of folic acid supplements does not appear to be associated with reduced rates of cardiovascular events, cancer or death over a five-year period. ANI

Urine LAM-ELISA not effective as independent diagnostic test for pulmonary TB

A trial of the new diagnostic urine LAM-ELISA has indicated that it may not be useful as an independent diagnostic test for pulmonary tuberculosis (TB).


Washington, August 28 : A trial of the new diagnostic urine LAM-ELISA has indicated that it may not be useful as an independent diagnostic test for pulmonary tuberculosis (TB).

Detailed in the open access journal BMC Infectious Diseases, the results suggest that it was only capable of identifying 50.7 per cent of TB cases.

Klaus Reither led a team of researchers from the Ludwig-Maximilians-University of Munich, Germany, the University College London, UK, and the NIMR-Mbeya Medical Research Programme, Tanzania, who tested LAM-ELISA in 291 Tanzanian patients suspected of having TB.

He said: "Only 35 out of 69 pulmonary TB cases, confirmed by smear microscopy and/or solid culture and/or liquid culture, showed at least one positive LAM-ELISA result. This 50.7 per cent sensitivity of the LAM-ELISA was disappointingly low. The specificity of 87.8 % also fell far short of expectations."

The LAM-ELISA detects lipoarabinomannan (LAM), a mycobacterium-specific lipopolysaccharide component of the bacilli's cell wall.

In active mycobacterial disease, LAM is released into the blood and passes the renal barrier without major changes - suggesting that its detection in urine should be a reliable diagnostic indicator.

Urine can be easily obtained, and its collection is often more culturally accepted than the collection of sputum or blood samples.

The LAM-ELISA might not have fulfilled the requirements for a stand-alone diagnostic test for pulmonary tuberculosis, but the researchers speculate that it may still be of some use.

"In our opinion, further investigations are needed to elucidate if the LAM-ELISA, in this stage of development, is valuable as a supplemental tool for the diagnosis of HIV-associated TB. This seems particularly important, when taking into consideration that TB is one of the most important opportunistic infections of HIV patients and that the sensitivity of smear microscopy in immunocompromised patients is low," they say.

ANI

Link to this page

Suggested pages for your additional reading
AndhraNews.net on Facebook






© 2000-2017 AndhraNews.net. All Rights Reserved and are of their respective owners.
Disclaimer, Terms of Service & Privacy Policy | Contact Us