|
| Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Bullion ~ Forex ~ Sports ~ Technology ~ Health ~ Features |
| Lung Cancer ~ Lung Cancer ~ Breast Cancer ~ Heart attack ~ All Health Topics |
|
Home
/ Health News / 2008 / October 2008 / October 2, 2008 Scientists see how HIV matures into AIDS |
Sack lunches may not provide adequate nutrients to preschooler
Packing lunch for your child might not be a good idea, for a new study has found that sack lunches may not regularly provide adequate nutrients for the growth and development of young children. ANI
Health-monitoring system helps maintain older adults well-being
Many older adults want to remain active and independent for as long as possible. Now, researchers from University of Missouri suggest that installing health monitoring system can help keep check on the health of the elderly and ensure their privacy. ANI
New drug shows potential to treat angina, other cardiac problems
A compound, designed to prevent chest pains in heart patients, could act as a drug to treat angina and possibly other cardiac pathologies, according to a study on animals. ANI
Researchers at the University of Missouri have ctually watched the HIV-1 protease mature from an inactive form into an active infection.
London, Oct 2 : Researchers at the University of Missouri have ctually watched the HIV-1 protease mature from an inactive form into an active infection.
This is the first time the process has been directly seen.
"We actually saw the process occur. This is something that has never been done before. We now understand more about the maturation process. We hope this will be a stepping stone to intervening before the infection progresses," Nature quoted Chun Tang, assistant professor of biochemistry in the MU School of Medicine, as saying.
The HIV-1 protease is behind releasing the essential building blocks of an infective HIV-1 viral particle, the culprit of AIDS.
The HIV-1 protease is one of the primary targets of therapeutic treatment. However, the viral enzyme is constantly mutating in an effort to gain drug resistance.
"HIV-1 protease is not an active enzyme when it is first expressed in cells. It has to be activated to do its job. What we were able to see is how it self-activates from an immature form when the virus is not infective into a mature form when the virus gains infectivity." Tang said.
The researchers used a novel NMR method called paramagnetic resonance relaxation enhancement and were able to see the temporary joining of two halves of HIV-1 protease precursor, something that had not been accessible before using conventional techniques.
They found that the 'tail,' or the flanking amino acid residues, of the HIV-1 protease precursor go through a temporarily formed tunnel where the tail is cut off.
At this point, the protease becomes active, the maturation process proceeds, and the virus becomes infective.
"The more we understand about the virus, especially about the maturation into infection, the more we can do to identify novel therapeutics," Tang said.
The findings appear today in the journal Nature.
ANI
