University of Leicester

Studying how nitric oxide alters brain function can lead to Alzheimers treatment

A team of British researchers has found that nitric oxide (NO) can change the computational ability of the brain.

Washington, November 27 : A team of British researchers has found that nitric oxide (NO) can change the computational ability of the brain.

Experts at the Medical Research Council (MRC) Toxicology Unit at the University of Leicester say that their new finding has implications for the treatment of neurodegenerative diseases like Alzheimer's Disease.

Professor Ian Forsythe, who led the study at the university, said that the new findings might also help advance scientists' understanding of brain function more generally.

"It is well known that nerve cells communicate via the synapse - the site at which chemical messengers (neurotransmitters such as acetylcholine or glutamate) are packaged and then released under tight control to influence their neighbours," Professor Forsythe, of the MRC Toxicology Unit, said in a research paper published in the journal Neuron.

"Nitric oxide is a chemical messenger which cannot be stored and can rapidly diffuse across cell membranes to act at remote sites (in contrast to conventional neurotransmitters which cannot pass across cell membranes).

"It is broadly localized in the central nervous system, where it influences synaptic transmission and contributes to learning and memory mechanisms. However, because it is normally released in such minute quantities and is so labile, it is very difficult to study.

"We have exploited an in vitro preparation of a giant synapse -called the calyx of Held, developed here at the University of Leicester in the 1990s- and its target in the auditory pathway to explore nitric oxide signalling in the brain.

"We show that NO is made in response to incoming synaptic activity (activity generated by sound received by the ear) and that it acts to suppress a key potassium ion-channel (Kv3). Normally these ion-channels keep electrical potentials very short-lived, but nitric oxide shifts their activity, slowing the electrical potentials and reducing information passage along the pathway, acting as a form of gain control.

"Surprisingly, the whole population of neurons were affected, even those neurons which had no active synaptic inputs, so indicating that nitric oxide is a 'volume transmitter' passing information between cells without the need for a synapse. Such a function is ideal for tuning neuronal populations to global activity. On the other hand, too much nitric oxide is extremely toxic and will cause death of nerve cells; so within the kernel of this important signalling mechanism are the potential seeds for neurodegeneration, which if left unchecked contribute to the pathologies of stroke and dementias," the researcher added.

Professor Forsythe revealed that his research team will be trying to understand how these signalling mechanisms are applicable elsewhere in the brain, and how aberrant signalling contributes to neurodegenerative disease processes such as in Alzheimer's disease.

ANI