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/ Health News / 2008 / July 2008 / July 11, 2008 Study gives new insight into protein that keeps skin cancer in check |
Sack lunches may not provide adequate nutrients to preschooler
Packing lunch for your child might not be a good idea, for a new study has found that sack lunches may not regularly provide adequate nutrients for the growth and development of young children. ANI
Health-monitoring system helps maintain older adults well-being
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New drug shows potential to treat angina, other cardiac problems
A compound, designed to prevent chest pains in heart patients, could act as a drug to treat angina and possibly other cardiac pathologies, according to a study on animals. ANI
Researchers at Oregon Health and Science University, Portland, have shed new light on the role of the signaling molecule Smad2 in skin cancer.
Washington, July 11 : Researchers at Oregon Health and Science University, Portland, have shed new light on the role of the signaling molecule Smad2 in skin cancer.
Xiao-Jing Wang and colleagues from the university provided the new insights by analysing human skin cancer tissue and a mouse model of skin cancer.
In the study, human squamous cell skin cancer samples were found to frequently lose expression of Smad2.
In particular, Smad2 expression was lost in all samples characterized as 'poorly differentiated' (which means they had progressed to become aggressive tumours).
Consistent with this, mice lacking Smad2 in cells of the skin known as keratinocytes developed chemically induced skin cancer more rapidly than normal mice, and the cancers were all characterized as 'poorly differentiated'.
The mouse cancers also underwent a process known as epithelial-mesenchymal transition (EMT) and this was found to contribute to the accelerated progression of the skin cancer to an aggressive form.
These data identify Smad2 as a suppressor of skin cancer development and progression to an aggressive form, and future studies will investigate in more detail the mechanisms underlying the role of Smad2 loss in human skin cancer progression.
ANI
