|
| Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Bullion ~ Forex ~ Sports ~ Technology ~ Health ~ Features |
| Lung Cancer ~ Lung Cancer ~ Breast Cancer ~ Heart attack ~ All Health Topics |
|
Home
/ Health News / 2008 / August 2008 / August 27, 2008 Sea sponges chemical can trigger cancer cell death |
Sack lunches may not provide adequate nutrients to preschooler
Packing lunch for your child might not be a good idea, for a new study has found that sack lunches may not regularly provide adequate nutrients for the growth and development of young children. ANI
Health-monitoring system helps maintain older adults well-being
Many older adults want to remain active and independent for as long as possible. Now, researchers from University of Missouri suggest that installing health monitoring system can help keep check on the health of the elderly and ensure their privacy. ANI
New drug shows potential to treat angina, other cardiac problems
A compound, designed to prevent chest pains in heart patients, could act as a drug to treat angina and possibly other cardiac pathologies, according to a study on animals. ANI
Researchers from National Cancer Institute in Frederick have revealed that a natural chemical found in sea sponges can trigger cancer cell death using an unusual pathway.
Washington, Aug 27 : Researchers from National Cancer Institute in Frederick have revealed that a natural chemical found in sea sponges can trigger cancer cell death using an unusual pathway.
The chemical called candidaspongiolide (CAN) stalls protein synthesis and also kills cancer cells by triggering caspase 12-dependent programmed cell death.
Previous studies have shown that CAN preferentially killed glioma and melanoma cells in vitro, but its mechanism was unknown.
In the new study led by Giovanni Melillo, M.D., of the National Cancer Institute in Frederick, Md, the researchers used molecular and cell assays to uncover the mechanism by which CAN kills cancer cells in vitro.
The researchers found that CAN halt protein synthesis in both normal and cancer cells but does not kill normal cells at dosages that trigger cell death in the malignant cells.
The chemical induces cell death by activating caspase 12 by an unusual biochemical pathway.
However, the investigators concluded that further tests with CAN are warranted in vitro and in animal models, which would provide greater insights in its mechanism.
ANI
