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/ Health News / 2008 / August 2008 / August 26, 2008 Drug, radiation therapy combo may help shrink established tumours |
Sack lunches may not provide adequate nutrients to preschooler
Packing lunch for your child might not be a good idea, for a new study has found that sack lunches may not regularly provide adequate nutrients for the growth and development of young children. ANI
Health-monitoring system helps maintain older adults well-being
Many older adults want to remain active and independent for as long as possible. Now, researchers from University of Missouri suggest that installing health monitoring system can help keep check on the health of the elderly and ensure their privacy. ANI
New drug shows potential to treat angina, other cardiac problems
A compound, designed to prevent chest pains in heart patients, could act as a drug to treat angina and possibly other cardiac pathologies, according to a study on animals. ANI
A new study has shown that anti cancer drugs combined with radiation therapy can help shrink well-established tumours.
Washington, Aug 26 : A new study has shown that anti cancer drugs combined with radiation therapy can help shrink well-established tumours.
Anti-cancer drugs such as Ipilimumab, boost the tumour-killing power of immune cells.
The immune system's tumour-fighting T cells are the most effective when maximally activated. Scientists have achieved this by blocking molecules that dampen the cells' activation, or by removing a population of regulatory T cells that block the killing ability of tumour-specific T cells.
But neither approach has worked well in patients with established tumours.
In a study conducted using mouse model, the researchers found that combining these two approaches caused small tumors to shrink but had no effect on large tumors, as blood vessels around large tumours lacked proteins required for killer T cells to crawl out of the circulation and into the tumour.
Radiation therapy has been shown to increase the expression of these vessel proteins.
The new study showed that combining the T cell-boosting treatment with radiation therapy was effective in shrinking large tumours.
The researchers would be conducting further studies to see whether combining radiation therapy with T cell-boosting drugs will be effective in humans.
The new study will be published online in the Journal of Experimental Medicine.
ANI
