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/ Health News / 2007 / September 2007 / September 25, 2007 Discovering biomarker of adenoma may help detect colorectal cancer |
Structure of key breast cancer target enzyme unraveled
A researcher at Hauptman-Woodward Medical Research Institute has moved a step closer to a cure, and possibly the prevention, of the most common type of breast cancer. ANI
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A new research has revealed that the absence of a newly discovered protein - mimecan - and upregulation of another protein - TXNDC5 - were involved in the early development of colorectal adenomas and cancers.
Washington, Sept 25 : A new research has revealed that the absence of a newly discovered protein - mimecan - and upregulation of another protein - TXNDC5 - were involved in the early development of colorectal adenomas and cancers.
The discovery is important as finding the biomarker of adenoma can improve the early detection and prevention of colorectal cancer.
Adenoma is a major precursor lesion of colorectal cancer, and shedding light on the molecular mechanism underlying adenoma is essential for early detection, prevention and intervention of colorectal cancer.
"Adenoma is a very important step in the development of cancer. Discovering the biomarker of adenoma will improve the early detection and prevention of cancer," Lai said.
Led by Maode Lai, a professor of molecular pathology at the Zhejiang University, Hangzhou, the research team found 27 differentially expressed proteins in colorectal adenoma using two dimensional electrophoresis (2-DE) and mass spectrometry. Western-blot analysis clearly validated 2 differentially expressed proteins, mimecan downregulation and TXNDC5 upregulation in colorectal adenomas and cancers.
"2-DE is an efficient traditional approach for the identification of differentially expressed proteins in cancer biology. Using this technology, we first identified 27 differentially expressed proteins in individual-matched colorectal normal, adenoma and cancer tissues," Lai said.
"This study found two novel proteins which have never been found to be associated with colorectal cancer. We clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer," the article's first author Yinghong Wang said.
"Our further work showed that mimecan could inhibit cell growth and induce cell apoptosis in colorectal cancer cells implying a candidate role as a tumor suppressor gene for the mimecan gene. These results suggested that mimecan might serve as a potential biomarker for future gene therapy," Wang added.
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, added: "Lai and his colleagues have performed a protein profiling proteomic study to understand the molecular mechanisms leading to colorectal cancer. It is this type of approach which can lead to the identification of biomarkers for the early detection of colorectal cancer, and targets for future gene therapy."
The research article describing the work entitled "Differential Expression of Mimecan and Thioredoxin Domain-Containing Protein 5 in Colorectal Adenoma and Cancer: A Proteomic Study" will be featured in the October 2007 issue of Experimental Biology and Medicine.
ANI
