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/ Health News / 2007 / October 2007 / October 17, 2007 New study of bone structure raises questions for osteoporosis treatment |
How cancer prevention drives aging
For the first time, researchers have found how cellular senescence, the well-known mechanism for preventing cancer, can trigger aging and age-related disease by changing the local tissue environment. ANI
Scientists unveil genes vital to vital to adult heart function
In a study on fruit fly Drosophila, scientists at the Burnham Institute for Medical Research (Burnham) have found that genes involved in embryonic heart development are vital to adult heart function in both fruit flies and humans. ANI
Psychiatric disorders common among college-aged
A new study has revealed that psychiatric disorders appear to be common among 18- to 24-year-olds, with overall rates similar among those attending or not attending college. ANI
A collaborative study by UK and Berlin researchers has found that human bone structure is very different from what it was previously believed.
Washington, Oct 17 : A collaborative study by UK and Berlin researchers has found that human bone structure is very different from what it was previously believed.
Dr David Reid of the Department of Chemistry at the University of Cambridge, who played a significant part in the research, says that the new findings may have sweeping impacts on treatments for osteoporosis and other bone disorders.
He revealed that the study has shown that the characteristic toughness and stiffness of bone is predominantly due to the presence of specialized sugars, not proteins, as was earlier thought.
During the study, the researchers studied mineralization in horse bones using an analysis tool called nuclear magnetic resonance (NMR).
They observed that sugars, particularly proteoglycans (PGs) and glycosaminoglycans (GAGs), appeared to play a role which is as important as proteins in controlling bone mineralization, the process by which newly-formed bone is hardened with minerals such as calcium phosphate.
"We believe our findings will alter some fundamental preconceptions of bone biology. On a practical level they unveil novel targets for drug discovery for bone and joint diseases, new biomarkers for diagnosis, and new strategies for developing synthetic materials that could be used in orthopaedics," Dr. Reid said.
"They may also strengthen the rationale for the current popularity of over-the-counter joint and bone pain remedies such as glucosamine and chondroitin, which are based on GAG sugar molecules," he added.
ANI
