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/ Health News / 2007 / October 2007 / October 1, 2007 The heart is its own best healer |
How binge drinking drives heart disease
Lack of exercise put depressed heart patients at greater risk
How cancer prevention drives aging
For the first time, researchers have found how cellular senescence, the well-known mechanism for preventing cancer, can trigger aging and age-related disease by changing the local tissue environment. ANI
Scientists unveil genes vital to vital to adult heart function
In a study on fruit fly Drosophila, scientists at the Burnham Institute for Medical Research (Burnham) have found that genes involved in embryonic heart development are vital to adult heart function in both fruit flies and humans. ANI
Psychiatric disorders common among college-aged
A new study has revealed that psychiatric disorders appear to be common among 18- to 24-year-olds, with overall rates similar among those attending or not attending college. ANI
Researchers in Bristol have found that hearts may develop innate protection against further damage after coronary disease.
Washington, October 1 : Researchers in Bristol have found that hearts may develop innate protection against further damage after coronary disease.
However, the same study has also shown that western-style high fat diets can significantly weaken this internal defence of the organ.
Saadeh Suleiman, Professor of Cardiac Physiology at the University of Bristol, and his colleagues at the Bristol Heart Institute modified the apoE gene in mice, which changed their cholesterol processing and made the rodents prone to fatty build-up in the coronary arteries, similar to human heart disease.
Thereafter, the genetically modified mice were fed a high-fat diet that is typically consumed by people in North America and the UK, causing them to develop coronary artery disease and suffer heart attack. On the other hand, mice fed a normal rodent diet for the same period did not develop coronary disease.
The researchers say that coronary disease seemed to have "preconditioned" the hearts, that is, it caused them to develop an innate protection against further damage.
According to them, this finding confirms a widely held belief that in certain heart attack survivors, the heart may become naturally preconditioned against further damage, and that when treating patients with coronary disease, surgeons and cardiologists have an advantage that can be further exploited to protect the heart.
The researchers also observed that though normal mice do not develop coronary disease upon being fed the same Western-type high-fat diet, they were much more vulnerable to injury than rodents fed normal diet in case their hearts were starved of blood supply, as happens in a heart attack of during surgery.
Professor Suleiman says that the finding is in complete contrast to the disease-prone animals, and suggests that Western style high-fat diet can significantly weaken the internal defences of the otherwise normally working heart and render it vulnerable to any sudden stress.
Based on their study's results, the researchers have come to the conclusion that western-style high-fat diets are not only bad for people with disease prone hearts, but also for individuals with healthy hearts.
"We have shown that in mice prone to developing coronary artery disease, a Western-style diet accelerates the progression of disease but that hearts with coronary disease then became more resistant to further damage, such as occurs during surgery. But it is still better to avoid surgery altogether by adopting healthy eating habits!" the researcher said.
ANI
