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Galapagos Delivers Candidate Drug in Osteoarthritis Alliance With Servier

July 24, 2012 - Mechelen, Belgium

- Galapagos NV (EURONEXT BRUSSELS: GLPG)announced todaythat it has identified the first pre-clinical candidate compound initsosteoarthritis alliance with Servier. The compound inhibits a novelmechanismof action discovered by Galapagos. This achievement triggered anundisclosedmilestone payment to Galapagos.

In July 2010, Servier and Galapagos announced their alliance to develop neworalmedicines for the treatment of osteoarthritis (OA). Galapagos isresponsiblefor the discovery and development of new candidate drugs, and Servier hasanexclusive option to license these after the completion of Phase Iclinicaltrials. Galapagos retains exclusive US commercialization rights toallcompounds discovered.

"OA is a disease of high unmet medical need, and progress of OA-therapieshasbeen slow in the pharma industry. We therefore are very pleased tohavedelivered a pre-clinical candidate," said Onno van de Stolpe, ChiefExecutiveOfficer of Galapagos. "This achievement also marks the third alliance withadifferent pharma partner in which Galapagos has identified a pre-clinicalcandidate. We are now starting with all the preparations to proceedfurtherinto Phase I."

"It is a major achievement in this therapeutic area where no disease-modifyingtreatments are currently available," said Bernard Marchand, Head ofDiscoveryResearch at Servier. "We are looking forward to seeing this compoundhopefullyenter the clinic after successful completion of the remaining pre-clinicalrequirements and are encouraged in our efforts to change the lives ofpeoplesuffering from this debilitating disease."

About Galapagos' osteoarthritis alliance with Servier

The alliance between Servier and Galapagos builds on novel osteoarthritisdrugtargets discovered by Galapagos through its proprietary platform. Foranymarketed products, Servier will have the rights to development, registrationandcommercialization, but Galapagos retains exclusive U.S.commercializationrights. Galapagos is also eligible to receive discovery,development,regulatory and other milestone payments that could reach EUR290 million,plusroyalties upon commercialization of products outside the U.S. covered undertheagreement.

About osteoarthritis

osteoarthritis (OA) is the most common form of arthritis, typicallyaffectingpeople aged 45 and older. It is a degenerative disease characterized byjointdestruction and loss of cartilage. No currently available treatments preventOAor even reverse or block the disease process. Treatment of OA involvesweightcontrol, exercise, and pain relief, most frequently with non-steroidalanti-inflammatory drugs (NSAIDs) that relieve the symptoms withoutchanging thecourse of the underlying disease. Many OA patients have pain thatpersistsdespite these measures and often then have to undergo costly surgicalproceduresto replace their damaged joints. It is expected that with the aging ofthepopulation, more individuals will be prone to develop OA. As mobilityofseniors is of high importance to maintaining a high quality of life,preventingthe severity of OA is seen as an immense clinical need over the next decade.

About Servier

Servier is a privately-run research based pharmaceutical company with a2011turnover of EUR3.9 billion. Servier is dedicating 25% of its turnover toResearch& Development in cardiovascular, metabolic, neurological, psychiatric andboneand joint diseases as well as oncology. Servier is established in 140countriesworldwide with over 20,000 employees. More info at:

About Galapagos

Galapagos (EURONEXT BRUSSELS: GLPG) (PINKSHEETS: GLPYY) is a mid-sizebiotechnology companyspecialized in the discovery and development of small molecule andantibodytherapies with novel modes-of-action. The Company is progressing itsJAK1inhibitor GLPG0634, as well as one of the largest pipelines in biotech,withfour programs in development and over 30 discovery programs. TheGalapagosGroup has about 800 employees and operates facilities in six countries,withglobal headquarters in Mechelen, Belgium. More info at:

This release may contain forward-looking statements, including,withoutlimitation, statements containing the words "believes,""anticipates,""expects," "intends," "plans," "seeks," "estimates," "may," "will,""could," and "continues," as well as similar expressions. Such forward-lookingstatements may involve known and unknown risks, uncertainties and otherfactorswhich might cause the actual results, financial condition, performanceorachievements of Galapagos, or industry results, to be materially differentfromany historic or future results, financial conditions, performanceorachievements expressed or implied by such forward-looking statements.Giventhese uncertainties, the reader is advised not to place any undue relianceonsuch forward-looking statements. These forward-looking statements speak onlyasof the date of publication of this document. Galapagos expressly disclaimsanyobligation to update any such forward-looking statements in this documenttoreflect any change in its expectations with regard thereto or any changeinevents, conditions or circumstances on which any such statement is based,unlessrequired by law or regulation.

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Source: Galapagos NV via Thomson Reuters ONE



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